NSC 46633 Chemical Properties

Boiling point:

238℃

Density 

1.106

Flash point:

97℃

storage temp. 

Inert atmosphere,Room Temperature

pka

10.51±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

Safety Information

HS Code 

2914390090

NSC 46633 Usage And Synthesis

Uses

2-Acetyl-6-methylphenol is used to prepare (hydroxyphenyl)(piperidinyl)pyridines as IκB kinase β inhibitors and orally active anti-inflammatory agents.

Preparation

Preparation by reaction of acetic acid on o-cresol with zinc chloride at reflux (Nencki reaction) (20%).

References

[1] Patent: US2014/349990, 2014, A1. Location in patent: Paragraph 0739; 0740
[2] Patent: WO2014/191896, 2014, A1. Location in patent: Page/Page column 147
[3] Organic and Biomolecular Chemistry, 2015, vol. 13, # 36, p. 9418 - 9426
[4] Patent: WO2014/191894, 2014, A1. Location in patent: Page/Page column 104; 105

NSC 46633(699-91-2)Related Product Information

• 2',5'-dimethyl-3'-nitroacetophenone
• 1-(3-BroMo-5-Methylphenyl)ethanone
• 2'-Fluoro-5'-Hydroxyacetophenone
• 2',5'-difluoro-4'-methoxyacetophenone
• 3'-(Difluoromethoxy)acetophenone
• 3',4'-dimethyl-5'-nitroacetophenone
• 3'-(TRIFLUOROMETHOXY)ACETOPHENONE
• 2',6'-Dibromo-4'-fluoroacetophenone
• 2-aMino-1-(2-broMophenyl)ethan-1-one hydrochloride
• 2-bromo-3'-chloro-5'-fluoroacetophenone
• Ethanone, 1-(2-chloro-5-hydroxyphenyl)-