3-METHYLTHIOPHENE-2-CARBOXAMIDE Chemical Properties

Melting point:

122-124°C

Boiling point:

269.3±28.0 °C(Predicted)

Density 

1.239±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

pka

15.85±0.50(Predicted)

BRN 

116188

Safety Information

Risk Statements 

22

Safety Statements 

22-36/37-36/37/39-26

RIDADR 

2811

PackingGroup 

III

HS Code 

29339900

MSDS

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3-METHYLTHIOPHENE-2-CARBOXAMIDE Usage And Synthesis

Chemical Properties

Light yellow solid

Preparation

3-Methyl-2-Thiophenecarboxamide synthesis: 1,2-Dichloroethane (280 mL), DMF (0.05 mL), 3-methyl-2-thiophenecarboxylic acid 5 (21.3 g, 0.149 mol), and SOCl2 (71.4 g, 43.8 mL, 0.6 mol) were heated at reflux temperature for 2 h with stirring. The solvent was then removed under vacuum to give 24 g of 3-methyl-2-thiophenecarbonyl chloride. This product was dissolved in 100 mL of CH2Cl2 and added to a solution of concentrated NH4OH (110 mL) in 300 mL CH2Cl2 with ice/salt bath cooling, at such a rate so as to maintain the reaction temperature below –5°C. The mixture was stirred for 20 min, separated, and the aqueous phase was extracted with another 200 mL of CH2Cl2. The combined organic layers were washed with water, then brine, and the solvent removed to give 21.2 g of 3-methyl-2-thiophenecarboxamide 15 as an off white solid, m.p. 123-124°C; 99.6% pure by GC area %; 1H NMR (CDCl3) 7.3 (d, 1H), 6.9 (1H), 5.8 (s, b), 2.5 ppm (s, 3H).

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