AMpicillin-d5 Chemical Properties

solubility 

Water: Slightly Soluble

form 

A solid

color 

White to off-white

Stability:

Hygroscopic

AMpicillin-d5 Usage And Synthesis

Description

Ampicillin-d₅ is intended for use as an internal standard for the quantification of ampicillin by GC- or LC-MS. Ampicillin is a broad-spectrum antibiotic with activity against Gram-positive and Gram-negative bacteria, including veterinary isolates of S. pseudintermedius, S. aureus, E. coli, Pasteurella, and S. canis (MIC₅₀s = 0.25, 0.5, 2, 0.12, and 0.25 μg/ml, respectively).¹ In vivo, ampicillin (80 mg/kg, i.v.) reduces cough frequency, tachypnea, dyspnea, and fever and increases survival in a baboon (P. cynocephalus) model of pneumococcal pneumonia.² Formulations containing ampicillin have been used to treat a variety of bacterial infections.

Uses

Labelled Ampicillin. Orally active, semi-synthetic antibiotic

References

1. Awji, E.G., Damte, D., Lee, S.-J., et al. The in vitro activity of 15 antimicrobial agents against bacterial isolates from dogs J. Vet. Med. Sci. 74(8),1091-1094(2012).
2. Reyes, L.F., Restrepo, M.I., Hinojosa, C.A., et al. A non-human primate model of severe pneumococcal pneumonia PLoS One 11(11),e0166092(2016).

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