ASPERLIN
ASPERLIN Basic information
- Product Name:
- ASPERLIN
- Synonyms:
-
- U 13933
- ASPERLIN
- ASPERLINE
- Asperlin (usan)
- D02999
- D-galacto-Oct-2-enonic acid, 6,7-anhydro-2,3,8-trideoxy-, δ-lactone, 4-acetate
- CAS:
- 30387-51-0
- MF:
- C10H12O5
- MW:
- 212.2
- Product Categories:
-
- Antibiotic
- Mol File:
- 30387-51-0.mol
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ASPERLIN Chemical Properties
- Boiling point:
- 360.4±42.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
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ASPERLIN Usage And Synthesis
Uses
Antibacterial; antineoplastic.
in vivo
Asperlin (40-80 mg/kg; p.o.; once daily for 12 weeks) effectively prevents the development of obesity, stimulates energy expenditure and modulates gut microbiota in high-fat diet (HFD)-fed mice[2].
Asperlin (80mg / kg; p.o.; once daily for 12 weeks) remarkably suppresses atherosclerotic plaque formation in the aorta, as revealed by the reduced aortic dilatation and decreased atherosclerotic lesion area in high-fat diet (HFD)-fed ApoE-/- mice[5].
| Animal Model: | C57BL/6J mice (8-weeks old, weighing 20-25g) were fed with a high-fat diet (HFD) to induce obesity[2] |
| Dosage: | 40, 80 mg/kg |
| Administration: | Oral gavage (p.o.), once daily for 12 weeks |
| Result: | Showed lower body weight, and food intake was not varied. Reduced the blood levels of total cholesterol (TC), triglycerides (TG) and low-density lipoprotein (LDL-c). Liver TC, TG contents and fat vacuoles were also substantially reversed. Increased energy expenditure and enhanced thermogenic gene (PGC1α, UCP1, CIDEA, CPT1B, FATP1, CYTO-C) expression in adipose tissue. Increased the diversity of the gut microbes. Significantly shifted the structure of the gut microbiota. |
| Animal Model: | Male C57BL/6 J and C57BL/6 J ApoE-/- mice (6-8 weeks, weighting 20-25 g)[5] |
| Dosage: | 80 mg/kg |
| Administration: | Oral gavage (p.o.), once daily for 12 weeks |
| Result: | Remarkably suppressed atherosclerotic plaque formation in aorta, reduced the white atherosclerotic lesions, effectively inhibited aortic dilatation in ApoE-/- mice. |
ASPERLINSupplier
BOC Sciences
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Zhejiang Huida Biotech Co., LTD
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- 0571-0571-89903882 15990081639
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