6-Cyclohexyl-3-(2-furanyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole Chemical Properties

storage temp. 

2-8°C

solubility 

DMSO: soluble5mg/mL (clear solution)

form 

powder

color 

white to beige

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

6-Cyclohexyl-3-(2-furanyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole Usage And Synthesis

Uses

A small molecule promoter affecting cardiomyocyte generation through modulation of the wnt signaling pathway.

Definition

ChEBI: Cardionogen-1 is a triazolothiadiazole that is [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole which is substituted at positions 3 and 6 by 2-furyl and cyclohexyl groups, respectively. A cardiomyocyte promoter and an inhibitor of Wnt/beta-catenin dependent transcriptional activity, it induces cardiac cell formation in murine stem cells and zebrafish embryos, expanding cardiac progenitor cells. A biphasic modulator of cardiogenesis, it can act as either a promotor or inhibitor of heart formation, depending on the stage of treatment. It has a role as a Wnt signalling inhibitor. It is a triazolothiadiazole and a member of furans.