1-Piperazinecarboxylic acid, 4-(4-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester
1-Piperazinecarboxylic acid, 4-(4-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester Basic information
- Product Name:
- 1-Piperazinecarboxylic acid, 4-(4-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester
- Synonyms:
-
- 1-Piperazinecarboxylic acid, 4-(4-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester
- tert-butyl 4-(4-aminopyridin-3-yl)piperazine-1-carboxylate
- Palbociclib Impurity SMA-4
- Palbociclib Impurity 82
- Tert-butyl 4-(4-aminopyridin-3-yl)Q: What is Tert-butyl 4-(4-aminopyridin-3-yl) Q: What is the CAS Number of Tert-butyl 4-(4-aminopyridin-3-yl)
- 1,1-Dimethylethyl 4-(4-amino-3-pyridinyl)-1-piperazinecarboxylate
- Palbociclib Impurity 126
- Palbociclib Impurity 104
- CAS:
- 1023594-50-4
- MF:
- C14H22N4O2
- MW:
- 278.35008
- Mol File:
- 1023594-50-4.mol
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1-Piperazinecarboxylic acid, 4-(4-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester Chemical Properties
- form
- Solid
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1-Piperazinecarboxylic acid, 4-(4-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester Usage And Synthesis
Uses
1,1-Dimethylethyl 4-(4-amino-3-pyridinyl)-1-piperazinecarboxylate is the impurity of Palbociclib (HY-50767). Palbociclib is an orally active selective CDK4 and CDK6 inhibitor with IC50 values of 11 and 16 nM, respectively[1].
References
[1] Fry DW, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004 Nov;3(11):1427-38. PMID:15542782
1-Piperazinecarboxylic acid, 4-(4-aMino-3-pyridinyl)-, 1,1-diMethylethyl esterSupplier
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1-Piperazinecarboxylic acid, 4-(4-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester(1023594-50-4)Related Product Information
- tert-butyl 4-(3-phenylpropyl)piperazine-1-carboxylate
- tert-Butyl 4-(4-amino-2-fluorophenyl)piperidine-1-carboxylate
- tert-Butyl 4-((6-bromopyridin-3-yl)methyl)piperazine-1-carboxylate
- tert-Butyl 4-(5-fluoro-2-nitrophenyl)-piperazine-1-carboxylate
- tert-butyl 4-(3-fluoro-4-nitrophenyl)piperazine-1-carboxylate
- 1-Piperazinecarboxylic acid, 4-(2-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester
- 4-(2-Nitro-4-trifluoromethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester
- tert-butyl 4-(2-amino-2-oxoethyl)-3-oxopiperazine-1-carboxylate
- 4-(5-Nitro-pyridin-2-yloxy)-piperidine-1-carboxylic acid tert-butyl ester
- tert-butyl 4-(4-amino-2,6-difluorophenyl)piperazine-1-carboxylate
- tert-butyl 4-(4-amino-3-(trifluoromethyl)phenyl)piperazine-1-carboxylate
- 4-(2-HYDROXY-PROPYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- tert-butyl 4-(3-bromo-6-chloropyridin-2-yl)piperazine-1-carboxylate
- tert-butyl 4-(5-nitro-1H-indol-3-yl)-5,6-dihydropyridine-1(2H)-carboxylate
- 4-(2-Amino-4-trifluoromethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester
- tert-butyl 4-((6-aminopyridin-3-yl)methyl)piperazine-1-carboxylate
- tert-butyl 4-(6-bromopyridin-3-yl)piperazine-1-carboxylate
- tert-butyl 4-(3-amino-5-(trifluoromethyl)phenyl)piperazine-1-carboxylate