AMINO[(3,4-DICHLOROBENZYL)SULFANYL]METHANIMINIUM CHLORIDE Chemical Properties

Melting point:

210 °C

storage temp. 

2-8°C

solubility 

H2O: soluble2mg/mL (clear solution, warmed)

form 

White solid

color 

white to beige

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2930909899

AMINO[(3,4-DICHLOROBENZYL)SULFANYL]METHANIMINIUM CHLORIDE Usage And Synthesis

Uses

MreB Perturbing Compound A22 is an isothiourea that reversibly perturbs MreB function.

Biochem/physiol Actions

A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been shown to act as an antiobiotic adjuvant. A22 inhibition of MreB disrupts the bacterial actin cytoskeleton, which can cause an increase in cell permeability and altered transport. A22 has been shown to have synergistic effects with several antibiotics including novobiocin and rifampin in gram negative bacteria.

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