DCB Chemical Properties

Melting point:

40 °C

Boiling point:

387.8±42.0 °C(Predicted)

Density 

1.21±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: ~6.8 mg/mL

form 

solid

pka

5.84±0.50(Predicted)

color 

yellow

InChI

1S/C14H10Cl2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H/b17-9+,18-10+

InChIKey

XMOVWXSCYLINBJ-BEQMOXJMSA-N

SMILES

Clc1cccc(\C=N\N=C\c2cccc(Cl)c2)c1

Safety Information

Hazard Codes 

Xn,N

Risk Statements 

22-37/38-41-43-50/53

Safety Statements 

26-36/37-60-61

RIDADR 

UN 3077 9/PG 3

WGK Germany 

3

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1
Eye Dam. 1
Skin Irrit. 2
Skin Sens. 1
STOT SE 3

MSDS

• Language:English Provider:SigmaAldrich

DCB Usage And Synthesis

Uses

DCB is an allosteric ligand for mGluR-5 (1). Regulates glutamate concentration however may induce neuronal damage through cerebral ischemia (2).

Biological Activity

Allosteric ligand for the metabotropic glutamate receptor mGlu 5 ; displays neutral modulation. Does not affect agonist-stimulated mGlu 5 responses, but blocks regulation of the receptor by other allosteric modulators such as DFB ([(3-Fluorophenyl)methylene]hydrazone-3-fluorobenzaldehyde ) and DMeOB ([(3-Methoxyphenyl)methylene]hydrazone-3-methoxybenzaldehyde ).

IC 50

mGluR 5

DCB(6971-97-7)Related Product Information

• SALOR-INT L497304-1EA
• DCB