Basic information Safety Supplier Related

IMETIT DIHYDROBROMIDE

Basic information Safety Supplier Related

IMETIT DIHYDROBROMIDE Basic information

Product Name:
IMETIT DIHYDROBROMIDE
Synonyms:
  • S-[2-(IMIDAZOL-4-YL)ETHYL]ISOTHIOUREA DIHYDROBROMIDE
  • 5-[2-(IMIDAZOL-4-YL)ETHYL]ISOTHIOUREA DIHYDROBROMIDE
  • IMETIT DIHYDROBROMIDE
  • IMETIT DIHYDROBROMIDE POTENT AND SELECTI VE
  • S-[2-(Imidazol-4-yl)ethyl]isothiourea2HBr
  • CarbaMiMidothioic acid, 2-(1H-iMidazol-4-yl)ethyl ester, dihydrobroMide
  • S-[2-(4(5)-Imidazolyl)ethyl]isothiourea dihydrobromide
  • SKF 91105 dihydrobromide
CAS:
32385-58-3
MF:
C6H12Br2N4S
MW:
332.06
Mol File:
32385-58-3.mol
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IMETIT DIHYDROBROMIDE Chemical Properties

storage temp. 
Store at RT
solubility 
H2O: soluble
form 
solid
color 
off-white
Water Solubility 
Freely soluble in water, practically insoluble in acetone /n
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3

MSDS

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IMETIT DIHYDROBROMIDE Usage And Synthesis

Description

Imetit is a histamine H3 and H4 receptor agonist (Kis = 0.3 and 2.7 nM, respectively, in radioligand binding assays). It is selective for histamine H3 and H4 receptors over H1 and H2 receptors at concentrations up to 100 μM, as well as the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 240 nM)., Imetit reduces potassium-induced increases in histamine levels in isolated rat cerebral cortex slices (EC50 = 2.8 nM). It increases scratching in mice (ED50 = 0.9 μmol), an effect that is reduced by the H3 receptor antagonist thioperamide .

Uses

Imetit dihydrobromide is a high affinity agonist at the histamine H3- and H4-receptors.

Definition

ChEBI: A hydrobromide salt obtained by reaction of imetit with two equivalents of hydrobromic acid. An extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces sh pe change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration.

Biological Activity

An extremely potent, high affinity agonist at H 3 and H 4 receptors (K i values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC 50 of 25 nM. Centrally active following systemic administration. Also available as part of the Histamine H 3 Receptor Tocriset™ .

Biochem/physiol Actions

Potent and selective H3 histamine receptor agonist.

storage

Store at RT

IMETIT DIHYDROBROMIDESupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Email
info@sagechem.com
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
EMMX Biotechnology LLC
Tel
888-539-0666
Email
info@emmx.com
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