Bis-PEG9-PFP ester
Bis-PEG9-PFP ester Basic information
- Product Name:
- Bis-PEG9-PFP ester
- Synonyms:
-
- Bis-PEG9-PFP ester
- Bis-dPEG(R)13-PFP ester
- Bis-dPEG(R)9-PFP ester
- 4,7,10,13,16,19,22,25,28-Nonaoxahentriacontanedioic acid, 1,31-bis(2,3,4,5,6-pentafluorophenyl) ester
- 9-PFP ester
- Bis-dPEG®
- bis(2,3,4,5,6-pentafluorophenyl) 4,7,10,13,16,19,22,25,28-nonaoxahentriacontanedioate
- Bis-dPEG?13-PFP ester
- CAS:
- 1334170-00-1
- MF:
- C34H40F10O13
- MW:
- 846.66
- Mol File:
- 1334170-00-1.mol
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Bis-PEG9-PFP ester Chemical Properties
- storage temp.
- -20°C
- solubility
- Soluble in DMSO, DCM
- form
- solid or viscous liquid
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Bis-PEG9-PFP ester Usage And Synthesis
Description
Bis-PEG9-PFP ester is a PEG linker with two activated PFP ester moieties. PFP esters can react with amine groups to form amide bonds. They are also less susceptible to undergo hydrolysis compared to other amine reactive groups. The hydrophilic PEG linker increase the water solubility of the compond in aqueous media.
Uses
Bis-PEG9-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
reaction suitability
reagent type: cross-linking reagent
reactivity: amine reactive
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
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