COX-2 INHIBITOR I Chemical Properties

Melting point:

177-179 °C

Boiling point:

604.3±55.0 °C(Predicted)

Density 

1.35±0.1 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

methanol: 1mg/mL
DMSO: 100mg/mL

form 

solid

color 

white

COX-2 INHIBITOR I Usage And Synthesis

Uses

COX-2-IN-5 (compound 11a) is a potent COX-2 inhibitor with an IC50 value of 0.65 μM. COX-2-IN-5 has the potential for the research of inflammation[1].

Definition

ChEBI: LM-1685 is an indolyl carboxylate ester that is methyl 1H-indole-2-carboxylate substituted by a 4-chlorobenzyl group at position 1 and a methylsulfonyl group at position 5. It acts as a selective inhibitor of cyclooxygenase 2. It has a role as a cyclooxygenase 2 inhibitor. It is an indolyl carboxylate ester, a sulfone, a member of monochlorobenzenes and a methyl ester.

Biological Activity

Cell permeable: yes', 'Primary Target
COX-2 from human monocytes', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 650 nM against COX-2 from human monocytes; 4.3 μM against COX-2 in whole blood

IC 50

COX-2: 0.65 μM (IC₅₀)

References

[1] Palomer A, et al. Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J Med Chem. 2002 Mar 28;45(7):1402-11. DOI:10.1021/jm010458r