DIETHYL 4-OXOCYCLOHEXANE-1,1-DICARBOXYLATE Chemical Properties

Boiling point:

175 °C(Press: 0.5 Torr)

Density 

1.155

storage temp. 

Sealed in dry,Room Temperature

Appearance

Colorless to off-white Solid

InChI

InChI=1S/C12H18O5/c1-3-16-10(14)12(11(15)17-4-2)7-5-9(13)6-8-12/h3-8H2,1-2H3

InChIKey

GDAVCKWOYPPSEU-UHFFFAOYSA-N

SMILES

C1(CCC(=O)CC1)(C(=O)OCC)C(=O)OCC

Safety Information

HS Code 

2902110000

DIETHYL 4-OXOCYCLOHEXANE-1,1-DICARBOXYLATE Usage And Synthesis

Synthesis

To 4,4-bis(ethoxycarbonyl)heptanedioic acid (23.6 g, 78 mmol) was added the compound in 100 mL of a premixed 10% (v/v) solution of pyridine and acetic anhydride. The reaction mixture was placed in a preheated oil bath heated to reflux with continuous stirring for 3 hours. After completion of the reaction, it was cooled to room temperature and concentrated under reduced pressure. The resulting oil was azeotropized twice with 95% ethanol (300 mL) and water (300 mL) and subsequently treated with solid potassium carbonate (12.9 g, 93.6 mmol). Concentrated under reduced pressure to remove ethanol, the remaining aqueous layer was diluted to redissolve the solid and then extracted with ether (2 x 150 mL). The organic phases were combined, dried over magnesium sulfate, and filtered. The filtrate was concentrated under reduced pressure to afford 4-oxo-1,1-cyclohexanedicarboxylic acid 1,1-diethyl ester (11.82 g, 48.8 mmol, 62.9% yield) as an amber-colored oil.HPLC analysis showed a retention time of 2.00 min (AP 74%); 1H NMR (500 MHz, CDCl3) δ ppm 4.24 (4H, q, J = 7.12 Hz), 2.44 (4H, t, J=6.56 Hz), 2.37 (4H, t, J=6.41 Hz), 1.27 (6H, t, J=7.17 Hz).

References

[1] Synthetic Communications, 1984, vol. 14, # 5, p. 401 - 406
[2] Patent: WO2012/78834, 2012, A1. Location in patent: Page/Page column 64-65
[3] Tetrahedron, 1958, vol. 3, p. 175
[4] Journal of Organic Chemistry, 1955, vol. 20, p. 1702,1707