STEAROYL-L-CARNITINE Chemical Properties

storage temp. 

2-8°C

solubility 

Water: 1 mg/mL (2.34 mM; ultrasonic and warming and heat to 80°C); DMSO: < 1 mg/mL (insoluble or slightly soluble)

form 

Solid

color 

White to off-white

optical activity

[α]/D -15±2°, c = 1 in methanol

BRN 

7309670

STEAROYL-L-CARNITINE Usage And Synthesis

Uses

Stearoyl-L-carnitine may be used as an analytical reference standard for the quantification of the analyte in biological fluids using chromatography-based techniques.

Definition

ChEBI: O-octadecanoyl-L-carnitine is an O-acyl-L-carnitine in which the acyl group is specified as stearoyl (octadecanoyl). It has a role as a human metabolite. It is functionally related to an octadecanoic acid.

General Description

Stearoyl-L-carnitine is a naturally occurring compound belonging to the acylcarnitine class of compounds as listed in the human metabolome database (HMBD). These compounds are reported to be used as biomarkers in the diagnosis of carnitine deficiency. It acts as a carrier of long chain acyl groups from activated fatty acids across the inner mitochondrial membrane into the mitochondrial matrix where they undergo β-oxidation to acetyl CoA to obtain usable energy via the citric acid cycle.

Biochem/physiol Actions

Stearoylcarnitine is found in significantly greater amounts in patients with carnitine palmitoyltransferase II deficiency. Carnitine palmitoyltransferase, in conjunction with acyl-CoA synthetase and carnitine/acylcarnitine translocase, provides the mechanism whereby long-chain fatty acids are transferred from the cytosol to the mitochondrial matrix to undergo beta-oxidation.

in vivo

IC 50

Human Endogenous Metabolite