GSK2837808A Chemical Properties

Boiling point:

783.5±70.0 °C(Predicted)

Density 

1.57±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

form 

crystalline solid

pka

3.81±0.10(Predicted)

color 

Light yellow to yellow

GSK2837808A Usage And Synthesis

Uses

GSK 2837808A may be lactate dehydrogenase A activity inhibitor.This compound is suitable for lactate dehydrogenase (LDH) related research.

Biological Activity

gsk2837808a is a potent, selective lactate dehydrogenase a (ldha) inhibitor (ic50 values are 1.9 and 14 nm for ldha and ldhb respectively).in snu398 but not hepg2 hepatocellular carcinoma cells. gsk2837808a (10 μm) reduces glucose consumption.after intravenous injection of gsk2837808a at 0.25 mg/kg in rats, the clearance is shown to be 69 ml/min/kg, which exceeds the blood flow of the animal liver. oral administration of gsk2837808a at 50 mg/kg or 100 mg/kg in rats or mice, respectively, resulted in blood compound levels reaching or below the detection limit of 2.5 ng/ml.[1]. billiard j, dennison j b, briand j, et al. quinoline 3-sulfonamides inhibit lactate dehydrogenase a and reverse aerobic glycolysis in cancer cells. cancer & metabolism, 2013, 1(1): 19-19.

in vivo

storage

Store at -20°C

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