AMG-747
AMG-747 Basic information
- Product Name:
- AMG-747
- Synonyms:
-
- AMG-747
- Tilapertin
- 2-[4-[(R)-phenyl-[3-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]acetic acid
- 1-Piperazineacetic acid, 4-[(R)-phenyl[3-(trifluoromethyl)phenyl]methyl]-
- CAS:
- 1000690-85-6
- MF:
- C20H21F3N2O2
- MW:
- 378.39
- Mol File:
- 1000690-85-6.mol
More
Less
AMG-747 Chemical Properties
- Boiling point:
- 455.3±45.0 °C(Predicted)
- Density
- 1.276±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- 4.24±0.10(Predicted)
More
Less
AMG-747 Usage And Synthesis
Uses
Tilapertin is an oral inhibitor of glycine transporter type-1 (GlyT1).
in vivo
Tilapertin is a nanomolar potent, orally bioavailable and selective GlyT1 inhibitor. Oral administration of Tilapertin dose-dependently increases cerebrospinal fluid (CSF) glycine concentration in rats[1].
IC 50
GlyT1
References
[1] Dunayevich E, et al. Efficacy and safety of the glycine transporter type-1 inhibitor AMG 747 for the treatment of negative symptoms associated with schizophrenia. Schizophr Res. 2017 Apr;182:90-97. DOI:10.1016/j.schres.2016.10.027
AMG-747Supplier
BOC Sciences
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
Fan De(Beijing) Biotechnology Co., Ltd.
- Tel
- 15911056312
- liming@bio-fount.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
HANGZHOU CLAP TECHNOLOGY CO.,LTD
- Tel
- 86-571-88216897,88216896 13588875226
- sales@hzclap.com
Shanghai Dexuan Pharmaceutical Technology Co., Ltd
- Tel
- 1701086315
- dexuanpharma@126.com