Basic information Safety Supplier Related

3'-Azido-3'-deoxy-5-methyl-beta-L-cytidine

Basic information Safety Supplier Related

3'-Azido-3'-deoxy-5-methyl-beta-L-cytidine Basic information

Product Name:
3'-Azido-3'-deoxy-5-methyl-beta-L-cytidine
Synonyms:
  • 3'-Azido-3'-deoxy-5-methyl-beta-L-cytidine
  • 3’-Azido-3’-deoxy-5-methyl-β-L-cytidine
  • 3'-Azido-3'-deoxy-5-methyl-b-L-cytidine
  • 3’-Azido-3’-deoxy-5-methyl-beta-L-cytidine
  • 1-methanesulfonyl-4-[1-(3-methyl-1H-pyrazole-5-carbonyl)pyrrolidin-3-yl]piperidine
CAS:
2095417-52-8
MF:
C10H14N6O4
MW:
282.26
Mol File:
2095417-52-8.mol
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3'-Azido-3'-deoxy-5-methyl-beta-L-cytidine Usage And Synthesis

Uses

3’-Azido-3’-deoxy-5-methyl-beta-L-cytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 3’-Azido-3’-deoxy-5-methyl-beta-L-cytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005

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