N6-Benzoyl-3'-O-(4,4'-dimethoxytrityl)-2'-O-t-butyldimethylsilyladenosine
N6-Benzoyl-3'-O-(4,4'-dimethoxytrityl)-2'-O-t-butyldimethylsilyladenosine Basic information
- Product Name:
- N6-Benzoyl-3'-O-(4,4'-dimethoxytrityl)-2'-O-t-butyldimethylsilyladenosine
- Synonyms:
-
- N6-Benzoyl-3'-O-(4,4'-dimethoxytrityl)-2'-O-t-butyldimethylsilyladenosine
- N6-Benzoyl-2'-O-tert-butyldimethylsilyl-3'-O-DMT-adenosine
- Adenosine, N-benzoyl-3'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-
- N6-Benzoyl-3’-O-(4,4’-dimethoxytrityl)-2’-O-t-butyldimethylsilyladenosine
- CAS:
- 1214886-17-5
- MF:
- C44H49N5O7Si
- MW:
- 787.97466
- Mol File:
- 1214886-17-5.mol
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N6-Benzoyl-3'-O-(4,4'-dimethoxytrityl)-2'-O-t-butyldimethylsilyladenosine Chemical Properties
- Density
- 1.23±0.1 g/cm3(Predicted)
- pka
- 14.44±0.10(Predicted)
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N6-Benzoyl-3'-O-(4,4'-dimethoxytrityl)-2'-O-t-butyldimethylsilyladenosine Usage And Synthesis
Uses
N6-Benzoyl-2'-O-tert-butyldimethylsilyl-3'-O-DMT-adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].
References
[1] Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500. DOI:10.1016/j.drudis.2021.02.020
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