3-Bromo-1-methyl-5-nitro-1H-pyridin-2-one Chemical Properties

storage temp. 

Sealed in dry,Room Temperature

Appearance

Off-white to light yellow Solid

Safety Information

HS Code 

2933399990

3-Bromo-1-methyl-5-nitro-1H-pyridin-2-one Usage And Synthesis

Synthesis

Under nitrogen protection, 0.55 g (3.57 mmol) of 1-methyl-5-nitro-2(1H)-pyridinone was dissolved in 10 mL of N,N-dimethylformamide. To this solution was added 0.76 g (4.27 mmol) of N-bromosuccinimide. The reaction mixture was stirred at 25 °C overnight. After completion of the reaction, the reaction mixture was diluted with dichloromethane and washed with water. The organic phase was dried with magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by a Biotage fast column using 70% ethyl acetate/hexane as eluent to give 0.60 g (72.15%) 3-bromo-1-methyl-5-nitropyridin-2(1H)-one as a white solid.1H NMR (CDCl3) δ: 3.75 (s, 3H), 8.53 (d, J = 2.8 Hz, 1H), 8.65 ( d, J = 2.8 Hz, 1H).

References

[1] Patent: WO2005/99688, 2005, A2. Location in patent: Page/Page column 140-141