Basic information Safety Supplier Related

Venetoclax D8

Basic information Safety Supplier Related

Venetoclax D8 Basic information

Product Name:
Venetoclax D8
Synonyms:
  • Venetoclax D8
  • VENETOCLAX-D8
  • Benzamide, 4-[4-[[2-(4-chlorophenyl)-4,4-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl-2,2,3,3,5,5,6,6-d8]-N-[[3-nitro-4-[[(tetrahydro-2H-pyran-4-yl)methyl]amino]phenyl]sulfonyl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-
  • Venetoclax-d8 (piperazine-d8)
  • Venetoclax-d8: 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4'-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl-2,2,3,3,5,5,6,6-d8)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide
  • D8-Venetoclax
CAS:
1257051-06-1
MF:
C45H42ClD8N7O7S
MW:
876.49
Mol File:
1257051-06-1.mol
More
Less

Venetoclax D8 Chemical Properties

form 
Solid
color 
Light yellow to yellow
More
Less

Venetoclax D8 Usage And Synthesis

Uses

Venetoclax-d8 is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy[1][2][3].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Souers AJ, et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med. 2013 Feb;19(2):202-8. DOI:10.1038/nm.3048
[3] Peirs S, et al. ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia. Blood. 2014 Dec 11;124(25):3738-47. DOI:10.1182/blood-2014-05-574566
[4] Bi C, et al. Inhibition of 4EBP phosphorylation mediates the cytotoxic effect of mechanistic target of rapamycin kinase inhibitors in aggressive B-cell lymphomas. Haematologica. 2017 Apr;102(4):755-764. DOI:10.3324/haematol.2016.159160

Venetoclax D8Supplier

ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Email
sales@chem-strong.com
Artis Biotech Co. Ltd.
Tel
028-67271278 18628360895
Email
sales@artisbio.com
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Email
3008007409@qq.com
Shanghai Champ Biopharmaceuticals Co., Ltd.
Tel
021-61537865 13585780846
Email
sales@champchem.com
Hubei Yangxin Medical Technology Co., Ltd.
Tel
15374522761
Email
3003392093@yongstandards.com