BAY57-1293 mesylate
BAY57-1293 mesylate Basic information
- Product Name:
- BAY57-1293 mesylate
- Synonyms:
-
- BAY57-1293 mesylate
- AIC316 mesylate
- Pritelivir mesylate
- Pritelivir mesylate (BAY 57-1293)
- N-Methyl-N-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide methanesulfonate
- CAS:
- 1428333-96-3
- MF:
- C19H22N4O6S3
- MW:
- 498.59
- Mol File:
- 1428333-96-3.mol
BAY57-1293 mesylate Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO : 83.33 mg/mL (167.13 mM; Need ultrasonic)
- form
- Solid
- color
- White to Off-White
BAY57-1293 mesylate Usage And Synthesis
Uses
BAY 57-1293 Methanesulfonate Salt is used in biological studies as an antiviral agents for treating and preventing shingles and a method of treating zoster(herpes) associated pain as it is a potent helicase primase inhibitor.
in vivo
Pritelivir is the first in a class of antiviral agents that inhibit HSV replication by targeting the viral helicase–primase enzyme complex[2].
Pritelivir (0.03-45 mg/kg) significantly increases survival. Pritelivir (0.3-30 mg/kg) reduces mortality against HSV-1, E-377. Pritelivir has potent and resistance-breaking antiviral efficacy with potential for the treatment of potentially life-threatening HSV type 1 and 2 infections, including herpes simplex encephalitis[3].
Combination therapies of Pritelivir at 0.1 or 0.3 mg/kg/dose with Acyclovir (10 mg/kg/dose) are protective when compared to the vehicle treated group against HSV-2, strain MS[3].
| Animal Model: | Female BALB/c mice[3] |
| Dosage: | 0.03 to 45 mg/kg |
| Administration: | Administered orally, twice daily at approximately 12 h intervals, for 7 days |
| Result: | Survival was significantly increased to 80-100% as compared to the vehicle treatment. Even the lowest dose of 0.3 mg/kg was effective in increasing survival to 53%. |
IC 50
HSV-1: 0.02 μM (IC50); HSV-2: 0.02 μM (IC50)
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