DSM265
DSM265 Basic information
- Product Name:
- DSM265
- Synonyms:
-
- DSM265
- DSM265;DSM265;DSM265
- 2-(1,1-Difluoroethyl)-5-methyl-N-[4-(pentafluoro-λ6-sulfanyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine
- DSM265,DSM-265
- 2-(1,1-Difluoroethyl)-5-methyl-N-(4-(pentafluoro-l6-sulfaneyl)phenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
- DSM265, 10 mM in DMSO
- CAS:
- 1282041-94-4
- MF:
- C14H12F7N5S
- MW:
- 415.33
- EINECS:
- 826-984-9
- Product Categories:
-
- API
- Mol File:
- 1282041-94-4.mol
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DSM265 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO:50.0(Max Conc. mg/mL);120.39(Max Conc. mM)
- form
- A solid
- color
- White to off-white
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DSM265 Usage And Synthesis
Uses
DSM265, inhibits the growth of P. falciparum 3D7 parasites with an EC50 of 4.3 nM. It is also a PfDHODH inhibitor with an IC50 of 8.9 nM.
in vivo
DSM265 (0.5 to 75 mg/kg; Oral administration; twice daily; for 4 days; NOD-scid IL-2Rγnull (NSG) mice) has potent in vivo antimalarial activity with 90% effective dose (ED90) of 3 mg/kg per day (1.5 mg/kg twice daily). The maximum rate of parasite killing occurred at and above a dose of 13 mg/kg per day (6.4 mg/kg twice daily).
DSM265 has moderate terminal elimination half-life (t1/2) of 2-4 hours for mice (0.5 to 75 mg/kg, oral) [2].
| Animal Model: | NOD-scid IL-2Rγnull (NSG) mice (23-36 g)[2] |
| Dosage: | 0.5 to 75 mg/kg |
| Administration: | Oral administration; twice daily; for 4 days |
| Result: | Had potent antimalarial activity with 90% effective dose (ED90) of 3 mg/kg per day (1.5 mg/kg twice daily). |
IC 50
Plasmodium
DSM265Supplier
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Fan De(Beijing) Biotechnology Co., Ltd.
- Tel
- 15911056312
- liming@bio-fount.com
Taizhou Crene Biotechnology Co. Ltd.
- Tel
- +86-0576-88813233 +86-13396860566
- sales@pharm-intermediates.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
Beijing xinyanhui pharmaceutical research and development co., LTD
- Tel
- 13969155946
- 1461866103@qq.com