p38-α MAPK-IN-1
p38-α MAPK-IN-1 Basic information
- Product Name:
- p38-α MAPK-IN-1
- Synonyms:
-
- p38-α MAPK inhibitor 1
- MAPK-IN-1
- MAPK14 INHIBITOR
- Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]phenyl]-
- p38-α MAPK-IN-1
- Inhibitor,inhibit,p-38-α MAPK-IN-1,Autophagy,p38α MAPKIN1,p38 MAPK,p38 α MAPK IN 1
- 1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-(2-morpholinoethoxy)phenyl)urea
- p38-α MAPK-IN-1, 10 mM in DMSO
- CAS:
- 443913-15-3
- MF:
- C27H35N5O3
- MW:
- 477.6
- Mol File:
- 443913-15-3.mol
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p38-α MAPK-IN-1 Chemical Properties
- Boiling point:
- 566.2±50.0 °C(Predicted)
- Density
- 1.19±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 100 mg/mL (209.38 mM);Water : < 0.1 mg/mL (insoluble)
- form
- Solid
- pka
- 13.76±0.70(Predicted)
- color
- White to off-white
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p38-α MAPK-IN-1 Usage And Synthesis
Uses
p38-α MAPK-IN-1 is an inhibitor of MAPK14 (p38-α), with IC50 of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay[1].
References
[1] Kluter S, et al. Displacement assay for the detection of stabilizers of inactive kinase conformations. J Med Chem. 2010 Jan 14;53(1):357-67. DOI:10.1021/jm901297e
p38-α MAPK-IN-1Supplier
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