diphenylterazine
diphenylterazine Basic information
- Product Name:
- diphenylterazine
- Synonyms:
-
- diphenylterazine
- DTZ
- Imidazo[1,2-a]pyrazin-3(7H)-one, 6,8-diphenyl-2-(phenylmethyl)-
- Diphenylterazine (DTZ)
- 2-Benzyl-6,8-diphenylimidazo[1,2-a]pyrazin-3(7H)-one
- Inhibitor,Diphenylterazine,inhibit
- CAS:
- 344940-63-2
- MF:
- C25H19N3O
- MW:
- 377.44
- Mol File:
- 344940-63-2.mol
diphenylterazine Chemical Properties
- Boiling point:
- 538.4±60.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- solubility
- DMSO:75.0(Max Conc. mg/mL);198.71(Max Conc. mM)
DMF:11.11(Max Conc. mg/mL);29.44(Max Conc. mM) - form
- A solid
- pka
- 6.33±0.40(Predicted)
- color
- Orange to reddish brown
- InChI
- InChI=1S/C25H19N3O/c29-25-21(16-18-10-4-1-5-11-18)27-24-23(20-14-8-3-9-15-20)26-22(17-28(24)25)19-12-6-2-7-13-19/h1-15,17,26H,16H2
- InChIKey
- HYQVAZNNCBIZSK-UHFFFAOYSA-N
- SMILES
- C12N=C(CC3=CC=CC=C3)C(=O)N1C=C(C1=CC=CC=C1)NC=2C1=CC=CC=C1
diphenylterazine Usage And Synthesis
Uses
Diphenylterazine (DTZ) is a bioluminescence agent. Diphenylterazine alone yielded very little background, leading to excellent signal-to-background ratios[1].
in vivo
Diphenylterazine injections into untransfected BALB/c mice do not yield any background emission. The bioluminescence resulting from intraperitoneally injected Diphenylterazine displays extended kinetics[1].
DTZ (0.3 μmol/mouse (1.13 mg.ml-1/100 ul/mouse); i.v.) treatment can track tumor growth in a xenograft NU/J mouse model[4].
References
[1] Yeh HW, et al. Red-shifted luciferase-luciferin pairs for enhanced bioluminescence imaging. Nat Methods. 2017 Oct;14(10):971-974. DOI:10.1038/nmeth.4400
[2] Yeh AH, et al. De novo design of luciferases using deep learning. Nature. 2023 Feb;614(7949):774-780. DOI:10.1038/s41586-023-05696-3
[3] Practical Notes for teLuc-DTZ and Antares2-DTZ (updated 07/29/2019).
[4] Hsien-Wei Yeh, et al. ATP-Independent Bioluminescent Reporter Variants To Improve in Vivo Imaging. ACS Chem Biol. 2019 May 17;14(5):959-965. DOI:10.1021/acschembio.9b00150
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