N3-PEG8-CH2COOtBu
N3-PEG8-CH2COOtBu Basic information
- Product Name:
- N3-PEG8-CH2COOtBu
- Synonyms:
-
- N3-PEG8-CH2COOtBu
- Azido-PEG8-C-Boc
- Azido-PEG8-CH2COOtBu
- Azido-PEG8-CH2COOH t-Bu Ester
- N3-PEG8-CH2COOtBu/3,6,9,12,15,18,21,24-Octaoxahexacosanoic acid, 26-azido-, 1,1-dimethylethyl ester
- CAS:
- 1984776-39-7
- MF:
- C22H43N3O10
- MW:
- 509.6
- Mol File:
- 1984776-39-7.mol
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N3-PEG8-CH2COOtBu Usage And Synthesis
Biological Activity
Azido-PEG8-C-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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