DSPE-PEG5-azide Chemical Properties

storage temp. 

-20°C, protect from light

solubility 

Soluble in DCM

form 

Solid

color 

White to off-white

DSPE-PEG5-azide Usage And Synthesis

Description

DSPE-PEG5-azide is a heterobifunctional PEG linker. The DSPE-PEGs have been FDA approved for medical applications. The hydrophobic properties of the DSPE allow for the encapsulation and congregation of other hydrophobic drugs. The hydrophilic PEG linker increases the water solubility of the overall compound allowing for the delivery of the drug. The azide group can undergo copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN.

Uses

DSPE-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DSPE-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

DSPE-PEG5-azide(2112737-73-0)Related Product Information

• DPPE-Azide
• DSPE-Alkyne
• DSPE-Maleimide
• DPPE-Alkyne
• DPPE-Maleimide
• DSPE-DBCO
• DPPE-DBCO
• DSPE-COOH
• L-ALPHA-PHOSPHATIDYL-ETHANOLAMINE DIPALMITOYL, N-SUCCINYL SODIUM SALT