IMD-0560
IMD-0560 Basic information
- Product Name:
- IMD-0560
- Synonyms:
-
- IMD-0560
- Benzamide, N-[2,5-bis(trifluoromethyl)phenyl]-5-bromo-2-hydroxy-
- IMD-0560,inhibit,I kappa B kinase,IMD0560,Inhibitor,IκB kinase,IKK,IMD 0560
- N-(2,5-Bis(trifluoromethyl)phenyl)-5-bromo-2-hydroxybenzamide
- CAS:
- 439144-66-8
- MF:
- C15H8BrF6NO2
- MW:
- 428.12
- Mol File:
- 439144-66-8.mol
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IMD-0560 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Ethanol : 50 mg/mL (116.79 mM)
- form
- Solid
- color
- White to off-white
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IMD-0560 Usage And Synthesis
Uses
IMD-0560 is a novel IκB kinase β inhibitor.
in vivo
The tumor size is reduced in the IMD-0560-treated groups in a dose-dependent manner, and no tumor is detected in some mice treated with 5 mg/kg IMD-0560. Zygoma destruction is significantly suppressed in the IMD-0560-treated groups compare to the control groups. Although the tumor size in the 5 mg/kg IMD-0560-treated group is smaller than that of the 3 mg/kg IMD-0560-treated group, the inhibitory effect of each treatment on zygoma destruction is similar[1].
IC 50
IKKβ
References
[1] Tada Y, et al. The novel IκB kinase β inhibitor IMD-0560 prevents bone invasion by oral squamous cell carcinoma. Oncotarget. 2014 Dec 15;5(23):12317-30. DOI:10.18632/oncotarget.2640
IMD-0560Supplier
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghai Beckham Medical Technology Co., Ltd
- Tel
- 13816613772
- huahero21@sina.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
Shanghai SuperLan Chemcial Technique Centre
- Tel
- 0-2022843681 15618226720
- chaolaichem@foxmail.com