3-Methyl-2-nitro-3H-imidazole-4-carboxylic acid methyl ester Chemical Properties

Boiling point:

374.6±34.0 °C(Predicted)

Density 

1.49±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

pka

-1.69±0.25(Predicted)

3-Methyl-2-nitro-3H-imidazole-4-carboxylic acid methyl ester Usage And Synthesis

Synthesis

1-methyl-2-nitro-1H-imidazole-5-carboxylic acid methyl ester 1c (50g, 0.27mol) was dissolve in 500mL tetrahydrofuran, followed by dropwise add methanol (13g, 0.4mol, 1.5eq) at 0 ℃. A solution of lithium hydride in tetrahydrofuran (2M, 202 mL, 1.5 eq) was added, and the reaction was incubated at 0 ℃ for 1 hour. The reaction solution was quenched by adding 500 mL of water, and extracted with ethyl acetate (500 mL × 3). The organic phases were combined, dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was added with dichloromethane (200 mL) and filtered to obtain 3-Methyl-2-nitro-3H-imidazole-4-carboxylic acid methyl ester(31 g, 0.2 mol, yellow solid), yield: 73%.

3-Methyl-2-nitro-3H-imidazole-4-carboxylic acid methyl ester(40361-79-3)Related Product Information

• 1-Methyl-2-nitro-1H-iMidazole-5-carboxylic acid
• methyl 2-amino-3-methyl-imidazole-4-carboxylate
• 3-Methyl-2-nitro-3H-imidazole-4-carboxylic acid methyl ester
• Methyl 4-imidazolecarboxylate
• (3-METHYL-2-NITRO-3H-IMIDAZOL-4-YL)-METHANOL
• 2-AMINO-1H-IMIDAZOLE-4-CARBOXYLIC ACID
• (2-AMINO-3-METHYL-3H-IMIDAZOL-4-YL)-METHANOL