BOC-BETA-CHLORO-ALA-OH Chemical Properties

Boiling point:

340.9±32.0 °C(Predicted)

Density 

1.247±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

pka

3.23±0.10(Predicted)

Appearance

White to off-white Solid

Safety Information

HazardClass 

IRRITANT

BOC-BETA-CHLORO-ALA-OH Usage And Synthesis

Chemical Properties

White to off-white powder

Synthesis

GENERAL STEPS: Example 1 Preparation of N-(tert-butoxycarbonyl)-3-chloro-L-alanine To a 50% aqueous 1,4-dioxane solution containing 1.0 g (6.25 mmol) of 3-chloro-L-alanine and 1.3 mL of triethylamine, 1.69 g (6.90 mmol) of 2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile was slowly added under stirring at room temperature. After the reaction lasted for 2 hours, the reaction mixture was poured into 20 mL of water and extracted twice with ethyl acetate. The organic layers were combined and washed sequentially with water twice and saturated brine once, followed by drying with anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give 0.66 g (40.5% yield) of white solid product. For further purification, recrystallization was carried out using a solvent mixture of ethyl acetate and n-hexane to give 0.58 g of pure product (35.6% yield) with a melting point of 123-124 °C (decomposition). The structure of the product was confirmed by IR and NMR analysis.

References

[1] Patent: US4888427, 1989, A

BOC-BETA-CHLORO-ALA-OH(71404-98-3)Related Product Information

• METHYL N-BOC-3-CHLORO-L-ALANINATE
• BOC-BETA-CHLORO-ALA-OH
• 3-CHLORO-L-ALANINE