Basic information Safety Supplier Related

7-AMINO-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLO[4,3-D]PYRIMIDINE MONOHYDRATE

Basic information Safety Supplier Related

7-AMINO-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLO[4,3-D]PYRIMIDINE MONOHYDRATE Basic information

Product Name:
7-AMINO-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLO[4,3-D]PYRIMIDINE MONOHYDRATE
Synonyms:
  • 3-d)pyrimidin-3-yl)-1,4-anhydro-1-c-(7-amino-1h-pyrazolo((s)-d-ribito
  • 3-d)pyrimidine,7-amino-3-beta-d-ribofuranosyl-1h-pyrazolo(
  • 7-amino-3-beta-d-ribofuranosyl-1h-pyrazolo(4,3-d)pyrimidine
  • formycin
  • 8-AZA-9-DEAZAADENOSINE MONOHYDRATE
  • 7-AMINO-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLO[4,3-D]PYRIMIDINE MONOHYDRATE
  • FORMYCIN MONOHYDRATE
  • FORMYCIN A MONOHYDRATE
CAS:
6742-12-7
MF:
C10H13N5O4
MW:
267.25
Mol File:
6742-12-7.mol
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7-AMINO-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLO[4,3-D]PYRIMIDINE MONOHYDRATE Chemical Properties

Melting point:
141-144 °C (decomp)
Boiling point:
709.5±60.0 °C(Predicted)
Density 
1.771±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMSO: soluble1mg/mL
form 
powder
pka
8.37±0.50(Predicted)
color 
white to off-white
BRN 
624229
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
UR0719000
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7-AMINO-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLO[4,3-D]PYRIMIDINE MONOHYDRATE Usage And Synthesis

Description

Formycin (Formycin A) is isolated from Nocardia interforma and from Streptomyces lavendulae , . The antibiotic is effective against Xanthomonas oryzae and Pellicularia filamentosa. Its activity against Yoshida rat sarcoma cell is enhanced by coformycin. Formycin B inhibits Xanthomonas oryzae and interferes with multiplication of influenza A virus in the cells of chick chorioallantoic membrane . Oxoformycin B shows no activity against Xanthomonas oryzae .

Uses

Formycin A (NSC 102811), a purine nucleoside antibiotic, is a potent human immunodeficiency virus type 1 (HIV-1) inhibitor with an EC50 of 10 μM. Formycin A shows antitumor and antiviral activities[1][2].

Definition

ChEBI: Formycin A is a formycin. It has a role as an antineoplastic agent.

IC 50

HIV-1: 10 μM (EC50)

References

[1] Dapp MJ , et al. Discovery of novel ribonucleoside analogs with activity against human immunodeficiency virus type 1.J Virol. 2014 Jan;88(1):354-63. DOI:10.1128/JVI.02444-13
[2] Zhang M, et al. Comparative Investigation into Formycin A and Pyrazofurin A Biosynthesis Reveals Branch Pathways for the Construction of C-Nucleoside Scaffolds. Appl Environ Microbiol. 2020 Jan 7;86(2). DOI:10.1128/AEM.01971-19

7-AMINO-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLO[4,3-D]PYRIMIDINE MONOHYDRATESupplier

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Zhejiang Huida Biotech Co., LTD
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mingxinzhu@huidabiotech.com
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