1H-INDOLE-3-CARBALDEHYDE N-(8-QUINOLINYL)HYDRAZONE
1H-INDOLE-3-CARBALDEHYDE N-(8-QUINOLINYL)HYDRAZONE Basic information
- Product Name:
- 1H-INDOLE-3-CARBALDEHYDE N-(8-QUINOLINYL)HYDRAZONE
- Synonyms:
-
- 1H-INDOLE-3-CARBALDEHYDE N-(8-QUINOLINYL)HYDRAZONE
- 8-[(E)-2-[(1H-indol-3-yl)methylidene]hydrazin-1-yl]quinoline
- LDK
- Lenaldekar
- 1H-Indole-3-carboxaldehyde, 2-(8-quinolinyl)hydrazone
- Lenaldekar, 10 mM in DMSO
- Lenaldekar (LDK)
- CAS:
- 418800-15-4
- MF:
- C18H14N4
- MW:
- 286.33
- Mol File:
- Mol File
1H-INDOLE-3-CARBALDEHYDE N-(8-QUINOLINYL)HYDRAZONE Chemical Properties
- Boiling point:
- 549.8±38.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 100mg/mL
- pka
- 11.02±0.70(Predicted)
- form
- powder
- color
- yellow
1H-INDOLE-3-CARBALDEHYDE N-(8-QUINOLINYL)HYDRAZONE Usage And Synthesis
Description
Lenaldekar is a inhibitor of T-cell expansion and autoimmune encephalomyelitis.
Uses
Lenaldekar (LDK) inhibits human and murine T-cell expansiomn. Lenaldekar inhibits autoimmune T cell response. Lenaldekar also induces cancer cell apoptosis. Lenaldekar can be used for T-cell mediated autoimmune diseases research[1][2].
in vivo
Lenaldekar (40 mg/kg per day, i.p.) inhibits experimental autoimmune encephalomyelitis (EAE) relapse in mice sensitized with the encephalitogenic PLP139-151 peptide[1].
Lenaldekar (16 mg/kg, i.p., twice daily) inhibits tumor progession in a mouse xenograft model of T-cell acute lymphoblastic leukemia (T-ALL)[2].
References
[1] Cusick MF, et al. Human T cell expansion and experimental autoimmune encephalomyelitis inhibited by Lenaldekar, a small molecule discovered in a zebrafish screen. J Neuroimmunol. 2012 Mar;244(1-2):35-44. DOI:10.1016/j.jneuroim.2011.12.024
[2] Ridges S, et al, et al. Zebrafish screen identifies novel compound with selective toxicity against leukemia. Blood. 2012 Jun 14;119(24):5621-31. DOI:10.1182/blood-2011-12-398818
1H-INDOLE-3-CARBALDEHYDE N-(8-QUINOLINYL)HYDRAZONESupplier
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