METRONIDAZOLE-D4 Chemical Properties

Melting point:

151-153°C

storage temp. 

Refrigerator

solubility 

DMSO (Slightly), Methanol (Very Slightly)

form 

Solid

color 

White to Pale Yellow

Safety Information

Hazard Codes 

Xn

Risk Statements 

40

Safety Statements 

36/37

METRONIDAZOLE-D4 Usage And Synthesis

Description

Metronidazole-d₄ is intended for use as an internal standard for the quantification of metronidazole by GC- or LC-MS. Metronidazole is an antibiotic that has activity against anaerobic bacteria and protozoa including T. vaginalis, E. histolytica, G. lamblia, C. difficile, and H. pylori. It reduces the growth of E. coli in vitro (MIC = 128 mg/L under anaerobic conditions). In vivo, metronidazole reduces viable counts of B. fragilis in a rabbit model of infection. Formulations containing metronidazole have been used in the treatment of various infections including H. pylori and C. difficile.

Chemical Properties

Pale Yellow Solid

Uses

Metronidazole-d4 is a labelled analog of Metronidazole (M338880). Used as an antibacterial in the treatment of rosacea. Antiprotozoal (trichomonas). A potential human carcinogen.

Uses

(Metronidazole-D4) Labelled Metronidazole (M338880). Used as an antibacterial in the treatment of rosacea. Antiprotozoal (trichomonas). A potential human carcinogen.

References

[1] SAMUELSON J. Why metronidazole is active against both bacteria and parasites.[J]. Antimicrobial Agents and Chemotherapy, 1999, 43 7: 1533-1541. DOI: 10.1128/aac.43.7.1533
[2] M RYLANDER. Activity of metronidazole on Bacteroides fragilis and/or Escherichia coli in vitro and in vivo.[J]. Journal of Antimicrobial Chemotherapy, 1981, 7 3: 257-267. DOI: 10.1093/jac/7.3.257

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