ONO-8590580
ONO-8590580 Basic information
- Product Name:
- ONO-8590580
- Synonyms:
-
- ONO-8590580
- 1H-Benzimidazol-6-amine, 1-(cyclopropylmethyl)-5-fluoro-4-methyl-N-[5-(1-methyl-1H-imidazol-4-yl)-2-pyridinyl]-
- 1-(cyclopropylmethyl)-5-fluoro-4-methyl-N-[5-(1-methyl-1H-imidazol-4-yl)pyridin-2-yl]-1H-1,3-benzodiazol-6-amine
- CS-2894
- ONO-8590580;ONO 8590580;ONO8590580
- 1-(Cyclopropylmethyl)-5-fluoro-4-methyl-N-[5-(1-methyl-1H-imidazol-4-yl)-2-pyridinyl]-1H-benzimidazol-6-amine
- γ-Aminobutyric acid Receptor,ONO8590580,Inhibitor,Gamma-aminobutyric acid Receptor,ONO-8590580,inhibit,GABA Receptor,ONO 8590580
- ONO-8590580, 10 mM in DMSO
- CAS:
- 1802661-73-9
- MF:
- C21H21FN6
- MW:
- 376.43
- Mol File:
- 1802661-73-9.mol
ONO-8590580 Chemical Properties
- Boiling point:
- 610.4±65.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble
- form
- A crystalline solid
- pka
- 4.95±0.10(Predicted)
- color
- White to off-white
ONO-8590580 Usage And Synthesis
Uses
ONO-8590580 is a GABAA α5 negative allosteric modulator.
in vivo
The effect of ONO-8590580 on the MK-801/scopolamine-induced cognitive deficit in the 8-arm radial maze test is investigated. Doses of MK-801 and scopolamine for this test are 0.075 mg/kg (i.p.) and 0.2 mg/kg (i.p.) respectively. ONO-8590580 (20 mg/kg, p.o.) significantly decreases the number of errors and total latency compared to the control. The present study in which ONO-8590580 but not donepezil significantly decreases the number of errors may suggest that ONO-8590580 could be more potent for the treatment of AD patients. The data showing that ONO-8590580 has not anxiogenic-like or proconvulsant effects are in agreement with the behavioral phenotype of α5-/- mice[1].
References
[1] Kawaharada S, et al. ONO-8590580, a Novel GABAAα5 Negative Allosteric Modulator Enhances Long-Term Potentiation and Improves Cognitive Deficits in Preclinical Models. J Pharmacol Exp Ther. 2018 Jul;366(1):58-65. DOI:10.1124/jpet.117.247627
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