TP-472 Chemical Properties

Density 

1.31±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: Soluble

form 

A solid

pka

14.98±0.20(Predicted)

color 

Light yellow to yellow

TP-472 Usage And Synthesis

Description

TP-472 is an inhibitor of bromodomain BRD9 (K_d = 33 nM; EC₅₀ = 320 nM in a NanoBRET assay). It has >30-fold selectivity over all other bromodomain family members with the exception of the highly homologous BRD7 bromodomain (K_d = 340 nM in an isothermal titration calorimetry (ITC) assay). See the Structural Genomic Consortium (SGC) website for more information.

storage

Store at -20°C