rac-7-hydroxy Propranolol (hydrochloride) Chemical Properties

Melting point:

210-211 °C (decomp)

storage temp. 

Store at -20°C

solubility 

DMSO: soluble

form 

A solid

rac-7-hydroxy Propranolol (hydrochloride) Usage And Synthesis

Description

rac-7-hydroxy Propranolol (hydrochloride) is a ring-hydroxylated isomer and metabolite of (±)-propranolol that is an antagonist at β-adrenergic receptors (0.95 potency relative to propranolol).¹ It also demonstrates potent vasodilator activity (0.20 potency relative to propranolol; pA₂ = 7.58).

References

1. Oatis, J.E., Jr., Russell, M.P., Knapp, D.R., et al. Ring-hydroxylated propranolol: Synthesis and β-receptor antagonist and vasodilating activities of the seven isomers J. Med. Chem. 24(3),309-314(1981).