17(R)-Resolvin D4 Chemical Properties

Boiling point:

609.2±55.0 °C(Predicted)

Density 

1.101±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 50 mg/ml; DMSO: unstable; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.5 mg/ml

pka

4.50±0.10(Predicted)

17(R)-Resolvin D4 Usage And Synthesis

Description

17(R)-Resolvin D4 (17(R)-RvD4) is an aspirin-triggered epimer of RvD4 .¹

Definition

ChEBI: Aspirin-triggered resolvin D4 is a member of the class of resolvins that is (6E,8E,10Z,13Z,15E,19Z)-docosahexaenoic acid carrying three hydroxy substituents at positions 4, 5 and 17 (the 4S,5R,17R-stereoisomer). It has a role as an anti-inflammatory agent, a human xenobiotic metabolite and a mouse metabolite. It is a resolvin, a secondary allylic alcohol, a triol and a hydroxy polyunsaturated fatty acid.

References

1. Serhan, C.N., Hong, S., Gronert, K., et al. Resolvins: A family of bioactive products of ω-3 fatty acid transformation circuits by aspirin treatment that counter proinflammation signals J. Exp. Med. 196(8),1025-1037(2002).