9(Z),11(Z)-Conjugated Linoleic Acid Chemical Properties

Melting point:

44 - 45oC

Boiling point:

381.6±11.0 °C(Predicted)

Density 

0.8802 g/cm3(Temp: 70 °C)

storage temp. 

Refrigerator, under inert atmosphere

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

pka

4.78±0.10(Predicted)

color 

White to Off-White

9(Z),11(Z)-Conjugated Linoleic Acid Usage And Synthesis

Description

9(Z),11(Z)-Conjugated linoleic acid is an isomer of linoleic acid that has been found in milk from cows and other animals. It is cytotoxic to Caco-2 human colon cancer cells (EC₅₀ = 446.1 μM) and induces changes in the miRNA profile, including an upregulation hsa-miR-146a-5p and downregulation of hsa-miR-32-5p, which is involved in apoptosis. [Matreya, LLC. Catalog No. 1248]

Uses

(9Z,11Z)-9,11-Octadecadienoic Acid, is a conjugated Linoleic Acid, a compound that has reported to exhibit anticarcinogenic activity. Linoleic Acid is an anti-inflammatory, acne reductive, and moisture retentive when applied topically on the skin. It is popular in the beauty products industry because of its beneficial properties on the skin.

Definition

ChEBI: 9Z,11Z-octadecadienoic acid is an octadecadienoic acid.

References

[1] MELISSA L. BAINBRIDGE . Milk from cows grazing on cool-season pastures provides an enhanced profile of bioactive fatty acids compared to those grazed on a monoculture of pearl millet[J]. Food Chemistry, 2017, 217: Pages 750-755. DOI: 10.1016/j.foodchem.2016.08.134
[2] I. REVILLA . Fatty acids and fat-soluble vitamins in ewe’s milk predicted by near infrared reflectance spectroscopy. Determination of seasonality[J]. Food Chemistry, 2017, 214: Pages 468-477. DOI: 10.1016/j.foodchem.2016.07.078
[3] SOLVEIGH K?PKE  Alfonso L  Thorsten Buhrke. miRNA Expression in Human Intestinal Caco-2 Cells is Comparably Regulated by cis- and trans-Fatty Acids[J]. Lipids, 2015, 50 3: 227-239. DOI: 10.1007/s11745-015-3988-x