TH1020
TH1020 Basic information
- Product Name:
- TH1020
- Synonyms:
-
- TH1020
- 4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine
- 4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2'
- TH1020 >=95% (HPLC)
- 4-((4-Benzyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine
- interaction,inhibit,Bacterial,flagellin,TH-1020,TH1020,Toll-like Receptor (TLR),TLR5,protein-protein,TNF-α,Inhibitor,TH 1020
- Pyrido[3',2':4,5]thieno[3,2-d]pyrimidine, 4-[[4-(phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-
- 4-((4-Benzyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine
- CAS:
- 1841460-82-9
- MF:
- C23H15N7S2
- MW:
- 453.54
- Mol File:
- 1841460-82-9.mol
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TH1020 Chemical Properties
- Boiling point:
- 765.8±70.0 °C(Predicted)
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform: 1 mg/ml
- form
- powder
- pka
- 1.92±0.10(Predicted)
- color
- white to beige
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TH1020 Usage And Synthesis
Uses
TH 1020 is a toll-like receptor 5 (TLR5)/flagellin complex inhibitor.
Uses
TH1020 has been used to inhibit toll-like receptor 5 (TLR5) in porcine intestinal epithelial monolayer cells and mice.
Biochem/physiol Actions
TH1020 is a non-cytotoxic non-cytotoxic toll-like receptor 5 (TLR5)/flagellin complex inhibitor. TH1020 selectively prevents flagellin-induced TLR5 signaling without affecting ligands-induced activation of TLR2, TLR3, TLR4, TLR7 or TLR8.
storage
Store at +4°C
TH1020Supplier
Jingmo (Xiamen) Biotechnology Co., Ltd Gold
- Tel
- 13621943973 13515979683
- sales@jamxmpharmatech.com
BOC Sciences
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
Sigma-Aldrich
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghai Chaolan Chemical Technology Center
- Tel
- QQ:65489617 15618227136
- info@SuperLan-chem.com