EZ-482
EZ-482 Basic information
- Product Name:
- EZ-482
- Synonyms:
-
- EZ-482
- EZ482,EZ 482
- 1-Phthalazineacetamide, N-[5-[[(3-chlorophenyl)amino]sulfonyl]-2-hydroxyphenyl]-3,4-dihydro-3-methyl-4-oxo-
- CAS:
- 1016456-76-0
- MF:
- C23H19ClN4O5S
- MW:
- 498.94
- Mol File:
- 1016456-76-0.mol
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EZ-482 Chemical Properties
- Density
- 1.49±0.1 g/cm3(Predicted)
- pka
- 6.69±0.50(Predicted)
- form
- Solid
- color
- White to off-white
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EZ-482 Usage And Synthesis
Uses
EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with Kds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas[1].
IC 50
apoE
References
[1] Tridib Mondal, et al. ApoE: In Vitro Studies of a Small Molecule Effector. Biochemistry. 2016 May 10;55(18):2613-21. DOI:10.1021/acs.biochem.6b00324
EZ-482Supplier
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Beijing Solarbio Science & Tecnology Co., Ltd.
- Tel
- 010-50973130 18101056239
- 3193328036@qq.com
Shanghai Hongye Biotechnology Co. Ltd
- Tel
- 400-9205774
- sales@glpbio.cn
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
- Tel
- 18818260767
- sales@chemegen.com