8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE
8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE Basic information
- Product Name:
- 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE
- Synonyms:
-
- DPCPX, PD 116,948
- 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE(DPCPX,1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE)
- cyclopentyl-1,3-dipropylxanthine
- 1,3-Dipropyl-8-cyclopentylxanthine, DPCPX, PD 116,948
- 1,3-Dipropyl-8-cyclopentyl-7H-purine-2,6(1H,3H)-dione
- 8-Cyclopentyl-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione
- 1,3-Dpcpx
- 1H-Purine-2,6-dione, 8-cyclopentyl-3,7-dihydro-1,3-dipropyl-
- CAS:
- 102146-07-6
- MF:
- C16H24N4O2
- MW:
- 304.39
- Product Categories:
-
- Adenosine receptor
- All Inhibitors
- Inhibitors
- Heterocycles
- Neurochemicals
- Mol File:
- 102146-07-6.mol
8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE Chemical Properties
- Melting point:
- 178°C
- Boiling point:
- 535.1±42.0 °C(Predicted)
- Density
- 1.195±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- DMSO: >10 mg/mL
- form
- solid
- pka
- 9.01±0.70(Predicted)
- color
- white
- Stability:
- Store tightly sealed at RT; Solutions at 4 deg C for several days
- CAS DataBase Reference
- 102146-07-6(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE Usage And Synthesis
Chemical Properties
White Solid
Uses
DPCPX is a potent and very selective A1-adenosine receptor antagonist, with a Ki of 0.46 nM for A1 receptors in rat whole-brain membranes. Its 740-fold A1-selectivity is the highest reported for an adenosine antagonist
Uses
8-Cyclopentyl-1,3-dipropylxanthine has been used as an adenosine receptor (A1AR) antagonist in macrophages and human umbilical vein endothelial cells (HUVECs). It has also been used as A1AR antagonist in MCF-7 breast cancer cell line to test its anti-cancer effect.
Definition
ChEBI: An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group.
Biological Activity
Potent and selective A 1 adenosine receptor antagonist, both in vitro and in vivo . K i values are 3.9, 130, 50 and 4000 nM for human A 1 , A 2A , A 2B and A 3 receptors respectively.
Biochem/physiol Actions
8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) is a selective A1?adenosine receptor antagonist. DPCPX possesses anti-cancer functionality. It induces apoptosis in breast cancer cells and favors mRNA expression of caspases.
storage
Room temperature
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8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE(102146-07-6)Related Product Information
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- Cyclohexylbenzene
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- 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE [DPCPX]
- KFM 19
- 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE
- CYCLOPENTYL-1,3-DIPROPYLXANTHINE, 8-[DIPROPYL-2,3-3H(N)]-
- MIDAXIFYLLINE
- [PROPYL-3H]8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE
- 8-CYCLOPENTYL-N3-[3-(4-(FLUOROSULFONYL)BENZOYLOXY)PROPYL]-N1-PROPYLXANTHINE
- 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE [DIPROPYL-2,3-3H]
- 1-BUTYL-8-(HEXAHYDRO-2,5-METHANOPENTALEN-3A(1H)-YL)-3,7-DIHYDRO-3-(3-HYDROXYPROPYL)-1H-PURINE-2,6-DIONE