Rho-Kinase-IN-1 Chemical Properties

Boiling point:

567.0±50.0 °C(Predicted)

Density 

1.25±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO: 50 mg/mL (141.84 mM; ultrasonic and warming and heat to 60°C)

form 

Solid

pka

14.39±0.40(Predicted)

color 

White to off-white

Rho-Kinase-IN-1 Usage And Synthesis

Uses

Rho-Kinase-IN-1 is a Rho kinase (ROCK) inhibitor (Ki values of 30.5 and 3.9 nM for ROCK1 and ROCK2, respectively) extracted from US20090325960A1, compound 1.008[1].

IC 50

ROCK1: 30.5 nM (Ki); ROCK2: 3.9 nM (Ki)

References

[1] Fulcher, Emilee H, et al. Method for the treatment and prevention of the inflammatory diseases using Rho kinase inhibiting compounds. US 20090325960 A1.