6-Fluoro-2-(2-methylphenyl)-1,2-benzisothiazol-3(2H)-one Chemical Properties

Boiling point:

397.9±52.0 °C(Predicted)

Density 

1.363±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: 50mg/mL

form 

Solid

pka

-2.59±0.20(Predicted)

color 

Off-white to yellow

6-Fluoro-2-(2-methylphenyl)-1,2-benzisothiazol-3(2H)-one Usage And Synthesis

Description

Thr101, also known as NOX Inhibitor VII, is a dose-dependent inhibitor of HDAC1, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9. Thr101 is also a NOX inhibitor.

Uses

Thr101 is an inhibitor (IC50=2.9 μM) of phosphomannose isomerase (PMI).PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia)[1].

Definition

ChEBI: 6-fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3-one is a member of benzothiazoles.

References

[1] Dahl R, et al. Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia. J Med Chem. 2011 May 26;54(10):3661-8. DOI:10.1021/jm101401a