Firuglipel
Firuglipel Basic information
- Product Name:
- Firuglipel
- Synonyms:
-
- Firuglipel
- 4-(5-((R)-1-(4-(Cyclopropanecarbonyl)phenoxy)propyl)-1,2,4-oxadiazol-3-yl)-2-fluoro-N-((R)-1-hydroxypropan-2-yl)benzamide
- Benzamide, 4-[5-[(1R)-1-[4-(cyclopropylcarbonyl)phenoxy]propyl]-1,2,4-oxadiazol-3-yl]-2-fluoro-N-[(1R)-2-hydroxy-1-methylethyl]-
- CAS:
- 1371591-51-3
- MF:
- C25H26FN3O5
- MW:
- 467.49
- Mol File:
- 1371591-51-3.mol
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Firuglipel Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- White to off-white
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Firuglipel Usage And Synthesis
Uses
Firuglipel (DS-8500a) is an orally available, potent and selective GPR119 agonist.
in vivo
Firuglipel (DS-8500a) (1-30 mg/kg) upregulates glucagon-like peptide-1 and enhances glucose-dependent insulin secretion and improves glucose homeostasis in type 2 diabetic rats[1].
References
[1] Matsumoto K, et al. DS-8500a, an Orally Available G Protein-Coupled Receptor 119 Agonist, Upregulates Glucagon-Like Peptide-1 and Enhances Glucose-Dependent Insulin Secretion and Improves Glucose Homeostasis in Type 2 Diabetic Rats. J Pharmacol Exp Ther. 2018 Dec;367(3):509-517. DOI:10.1124/jpet.118.250019
FiruglipelSupplier
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