2-((1H-benzo[d]imidazol-1-yl)methyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Chemical Properties

storage temp. 

room temp

solubility 

DMSO: 10mg/mL, clear

form 

powder

color 

white to brown

2-((1H-benzo[d]imidazol-1-yl)methyl)-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Usage And Synthesis

Uses

PF-06284674 (PKM2 activator 1) (Compound 8) is a PKM2 activator that can be used in cancer research[1].

Biological Activity

PF-06284674 is a cell permeable, potent and selective M2 isoform of pyruvate kinase (PKM2) activator.

References

[1] Guo C, et al. Discovery of 2-((1H-benzo [d] imidazol-1-yl) methyl)-4H-pyrido [1, 2-a] pyrimidin-4-ones as novel PKM2 activators[J]. Bioorganic & medicinal chemistry letters, 2013, 23(11): 3358-3363. DOI:10.1016/j.bmcl.2013.03.090