IMGN-779
IMGN-779 Basic information
- Product Name:
- IMGN-779
- Synonyms:
-
- DGN-462
- IMGN-779
- IMGN779-Linker
- 6H-Indolo[2,1-c][1,4]benzodiazepin-6-one, 9-[[3-[[[(12aS)-12a,13-dihydro-8-methoxy-6-oxo-6H-indolo[2,1-c][1,4]benzodiazepin-9-yl]oxy]methyl]-5-[(2-mercapto-2-methylpropyl)[2-[2-(2-methoxyethoxy)ethoxy]ethyl]amino]phenyl]methoxy]-11,12,12a,13-tetrahydro-8-methoxy-, (12aS)-
- CAS:
- 1394079-41-4
- MF:
- C53H59N5O9S
- MW:
- 942.13
- Mol File:
- 1394079-41-4.mol
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IMGN-779 Chemical Properties
- Density
- 1.31±0.1 g/cm3(Predicted)
- pka
- 10.88±0.10(Predicted)
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IMGN-779 Usage And Synthesis
Uses
DGN462, a potent DNA-alkylating agent, shows anti-tumor activity, such as acute myeloid leukemia (AML). DGN462 can be used as a cytotoxic component of antibody-drug conjugates (ADCs)[1].
References
[1] Hicks SW, et al. The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models. Haematologica. 2019 Aug;104(8):1633-1639. DOI:10.3324/haematol.2018.211011
IMGN-779Supplier
Kaixin Chemical (Hong Kong) Limited
- Tel
- 010-88886666-01 13112345678
- loyson@tcypharm.com
Abydos Scientific
- Tel
- 025-84767922 18936879710
- sales@abydoscientific.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
TargetMol Chemicals Inc.
- Tel
- 15002134094
- marketing@targetmol.cn
Selleck Chemicals
- Tel
- 400-668-6834
- info@selleck.cn