RO 90-7501
RO 90-7501 Basic information
- Product Name:
- RO 90-7501
- Synonyms:
-
- 2'-(4-aMinophenyl)-1H,3'H-2,5'-bibenzo[d]iMidazol-6-aMine
- RO90-7501; RO 907501
- 2'-(4-Aminophenyl)-1H,3'H-[2,5'-bibenzo[d]imidazol]-5-amine
- 2,5'-Bi-1H-benzimidazol]-5-amine, 2'-(4-aminophenyl)-
- CAS:
- 293762-45-5
- MF:
- C20H16N6
- MW:
- 340.388
- Mol File:
- 293762-45-5.mol
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RO 90-7501 Chemical Properties
- storage temp.
- Store at +4°C
- solubility
- DMSO: ~20mg/mL
- form
- solid
- color
- brown
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RO 90-7501 Usage And Synthesis
Uses
Ro 90-7501 exhibits antibacterial activity. In addition, it also promote both toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response.
Definition
ChEBI: 2-[2-(4-aminophenyl)-3H-benzimidazol-5-yl]-3H-benzimidazol-5-amine is a member of benzimidazoles.
Biological Activity
Inhibitor of amyloid β 42 (A β 42) fibril assembly; reduces A β 42-induced toxicity (EC 50 = 2 μ M).
in vivo
Ro 90-7501 (5 μg/g; intraperitoneal injection; daily; for 21 days; female BALB/c nude mice) treatment significantly delays tumor growth and significantly decreases tumor volume[1].
| Animal Model: | Female BALB/c nude mice (8-week-old) with HeLa cells under irradiation[1] |
| Dosage: | 5 μg/g |
| Administration: | Intraperitoneal injection; daily; for 21 days |
| Result: | Tumor growth was significantly delayed in the combination group. Tumor volume was also significantly decreased in the irradiation group. |
IC 50
Amyloid β42; ATM; Protein phosphatase 5; Apoptosis
storage
Store at +4°C
RO 90-7501Supplier
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
Shanghai Chaolan Chemical Technology Center
- Tel
- 021-QQ：65489617 15618227136
- Sales@ATKchemical.com
Beijing Jin Ming Biotechnology Co., Ltd.
- Tel
- 010-60605840 18892239720
- psaitong@jm-bio.com
Chuzhou KeMail Chemical Technology Co., Ltd
- Tel
- 0550-5196001 15000891977
- wj520wjxby@126.com