TYRPHOSTIN AG 1112
TYRPHOSTIN AG 1112 Basic information
- Product Name:
- TYRPHOSTIN AG 1112
- Synonyms:
-
- 1H-Pyrazole-3-acetonitrile, 5-amino-4-cyano-alpha-(1H-indol-3-ylmethyl ene), (Z)-
- 1H-Pyrazole-3-acetonitrile, 5-amino-4-cyano-α-(1H-indol-3-ylmethylene)-, (αZ)-
- Tyrphostin AG 1112 >=98%, solid
- CAS:
- 153150-84-6
- MF:
- C15H10N6
- MW:
- 274.28
- Product Categories:
-
- Casein Kinase (CK)Cell Signaling and Neuroscience
- P to
- Protein Kinase InhibitorsEnzyme Inhibitors by Enzyme
- Protein kinase, tyrosine, EGF receptor
- Serine/Threonine Kinase Biology
- Kinase/Phosphatase Biology
- Serine/Threonine Kinase Inhibitors
- Mol File:
- 153150-84-6.mol
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TYRPHOSTIN AG 1112 Chemical Properties
- storage temp.
- −20°C
- solubility
- DMSO: soluble
- form
- solid
- color
- off-white to yellow
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Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-40
- Safety Statements
- 26-36/37
- WGK Germany
- 1
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TYRPHOSTIN AG 1112 Usage And Synthesis
Uses
Tyrphostin AG1112 is a potent inhibitors of CK II. Tyrphostin AG1112 inhibits p210bcr-abl tyrosine kinase, with IC50 values of 2, 15, 20 μM in p210bcr-abl, EGFR and PDGFR cells, respectively[1][2].
References
[1] T B Kang, et al. Action of 3 tyrphostin derivatives on casein kinase II from rat liver. Zhongguo Yao Li Xue Bao. 1997 Jan;18(1):56-8. PMID:10072895
[2] M Anafi, et al. Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate. Blood. 1993 Dec 15;82(12):3524-9. PMID:7505115
TYRPHOSTIN AG 1112Supplier
Spectrum Chemical Manufacturing Corp.
- Tel
- 021-021-021-67601398-809-809-809 15221380277
- marketing_china@spectrumchemical.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
Energy Chemical
- Tel
- 021-58432009 400-005-6266
- marketing@energy-chemical.com
TargetMol Chemicals Inc.
- Tel
- 15002134094
- marketing@targetmol.cn
Santa Cruz Biotechnology Inc
- Tel
- 021-60936350
- scbt@scbt.com