1-(BETA-D-Xylofuranosyl)-5-methylcytosine Chemical Properties

Melting point:

205-207 °C(Solv: ethanol (64-17-5))

Boiling point:

537.5±60.0 °C(Predicted)

Density 

1.79±0.1 g/cm3(Predicted)

pka

13.48±0.70(Predicted)

1-(BETA-D-Xylofuranosyl)-5-methylcytosine Usage And Synthesis

Uses

1-(β-D-Xylofuranosyl)-5-methylcytosine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
[2] Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8. DOI:10.4161/cbt.3.11.1308