ARG-GLU(EDANS)-(ASN670,LEU671)-APP770 (668-675)-LYS(DABCYL)-ARG
ARG-GLU(EDANS)-(ASN670,LEU671)-APP770 (668-675)-LYS(DABCYL)-ARG Basic information
- Product Name:
- ARG-GLU(EDANS)-(ASN670,LEU671)-APP770 (668-675)-LYS(DABCYL)-ARG
- Synonyms:
-
- ARG-GLU(EDANS)-[ASN670, LEU671]-AMYLOID B/A4 PROTEIN PRECURSOR 770 FRAGMENT 669-674-(DABCYL)LYS-ARG
- ARG-GLU(EDANS)-(ASN670,LEU671)-AMYLOID BETA/A4 PROTEIN PRECURSOR770 (668-675)-LYS (DABCYL)-ARG
- ARG-GLU(EDANS)-(ASN670,LEU671)-APP770 (668-675)-LYS(DABCYL)-ARG
- ARG-GLU(EDANS)-GLU-VAL-ASN-LEU-ASP-ALA-GLU-PHE-LYS(DABCYL)-ARG
- Arg-Glu(EDANS)-(Asn670,Leu671)-Amyloid beta/A4 Protein Precursor770 (668-675)-Lys(DABCYL)-Arg trifluoroacetate salt
- H-ARG-GLU(EDANS)-GLU-VAL-ASN-LEU-ASP-ALA-GLU-PHE-LYS(DABCYL)-ARG-OH
- Arg-Glu(EDANS)-[Asn670, Leu671]-Amyloid β/A4 Precursor Protein 770 Fragment 669-674-(DABCYL)Lys-Arg
- Arg-Glu: EDANS-: Asn670,Leu671-Amyloid b/A4 Protein Precursor770: 668-675-Lys: DABCYL-Arg
- CAS:
- 310427-94-2
- MF:
- C91H129N25O25S
- MW:
- 2005.22
- Product Categories:
-
- Amyloid Precursor ProteinsNeuropeptides
- Other Amyloid Protein FragmentsEnzyme Substrates
- pro-beta-secretase (pro-memapsin 2)
- pro-beta-secretase (pro-memapsin 2)Enzyme Substrates
- β Amyloid Peptides
- Alzheimers and Neurodegenerative Disease Research
- Neurodegenerative Disease Peptides
- Protease Substrates
- Substrates by Enzyme
- Mol File:
- 310427-94-2.mol
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ARG-GLU(EDANS)-(ASN670,LEU671)-APP770 (668-675)-LYS(DABCYL)-ARG Chemical Properties
- storage temp.
- −20°C
- solubility
- DMSO: 5mg/mL
- form
- solid
- color
- red
- Sequence
- Arg-{Glu(EDANS)}-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-{Lys(DABCYL)}-Arg
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Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
MSDS
- Language:English Provider:SigmaAldrich
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ARG-GLU(EDANS)-(ASN670,LEU671)-APP770 (668-675)-LYS(DABCYL)-ARG Usage And Synthesis
Uses
RE (EDANS) EVNLDAEFK (DABCYL) R is an EDANS and DABCYL double-labeled peptide，serves as a fluorescent substrate for BACE1(Em=360nm，Ex=528nm). RE (EDANS) EVNLDAEFK (DABCYL) R can be used for BACE1 activity measurement and the enzyme activity level is directly proportional to the fluorescence reaction[1].
Biological Activity
Cell permeable: no', 'Primary Target
β-secretase substrate', 'Product does not compete with ATP.', 'Reversible: no
References
[1] Ortega A, et.al. Synthesis and evaluation of arylquinones as BACE1 inhibitors, β-amyloid peptide aggregation inhibitors, and destabilizers of preformed β-amyloid fibrils. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2183-7. DOI:10.1016/j.bmcl.2011.03.023
ARG-GLU(EDANS)-(ASN670,LEU671)-APP770 (668-675)-LYS(DABCYL)-ARGSupplier
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