Basic information Safety Supplier Related

EA4

Basic information Safety Supplier Related

EA4 Basic information

Product Name:
EA4
Synonyms:
  • EA4
  • 7-chloro-6-[4-(diethylamino)phenyl]quinoline-5,8-dione
  • 5,8-Quinolinedione, 7-chloro-6-[4-(diethylamino)phenyl]-
CAS:
389614-94-2
MF:
C19H17ClN2O2
MW:
340.8
Mol File:
389614-94-2.mol
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EA4 Chemical Properties

Boiling point:
508.3±50.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
-196°C
solubility 
≤1mg/ml in DMSO;20mg/ml in dimethyl formamide
form 
crystalline solid
pka
6.14±0.44(Predicted)
color 
Light blue to blue
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EA4 Usage And Synthesis

Biological Activity

ki: 130 μmea4 is a rpla2 inhibitor.rpla2, a calcium-dependent cytosolic phospholipase a2 (cpla2), was initially isolated and characterized from bovine and human red blood cells. with a molecular mass of 42 kda, cpla2 shows biochemical properties similar to cpla2 type iv.

in vitro

it was found that ea4 was able to inhibit a ca(2+) ionophore-induced arachidonic acid release from both human and bovine red blood cells, demonstrating that this enzyme was responsible for the ca(2+)-dependent arachidonic acid release from mammalian red blood cells [1]. another study found that in mouse hepatoma hepa-1c1c7 cells, ea4 could cause a significant induction of the cyp1a1-mediated ethoxyresorufin o-deethylase activity time- and concentration-dependently, and such induction was accompanied by an increase of the cyp1a1 mrna transcription. morevoer, in human cells including mcf-7 (human breast adenocarcinoma cell line), hepg2 (human hepatocarcinoma), and hl-60 (human promyelocytic cell line), the expression of cyp1a1 mrna could be also induced by ea4 treatment. in addition, cyp1b1 mrna was increased by ea4 in mcf-7 cells [2].

References

1. shin, h.s.,chin, m.r.,kim, j.s., et al. purification and characterization of a cytosolic, 42-kda and ca2+-dependent phospholipase a2 from bovine red blood cells. the journal of biological chemisty 277, 21086-21094 (2002).2. chun, y.j.,lee, b.y.,yang, s.a., et al. induction of cytochrome p450 1a1 gene expression by a vitamin k3 analog in mouse hepatoma hepa-1c1c7 cells. molecules and cells 12, 190-196 (2001).

EA4Supplier

BOC Sciences
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InvivoChem
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MedBioPharmaceutical Technology Inc
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021-69568360 18916172912
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InvivoChem
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13549236410
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