Basic information Safety Supplier Related

1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE

Basic information Safety Supplier Related

1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE Basic information

Product Name:
1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE
Synonyms:
  • 1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE
  • NASPM (hydrochloride)
  • 1-Naphthyl acetyl spermine (NASPM) trihydrochloride
  • Naspm trihydrochloride (1-Naphthylacetyl spermine)
  • inhibit,Inhibitor,Naspm trihydrochloride,iGluR,Ionotropic glutamate receptors
  • N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-2-(naphthalen-1-yl)acetamide trihydrochloride
CAS:
1049731-36-3
MF:
C22H35ClN4O
MW:
407
Product Categories:
  • Amines
  • Aromatics
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
Mol File
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1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE Chemical Properties

Melting point:
>253°C (dec.)
storage temp. 
desiccated protect from light
solubility 
H2O: 23 mg/mL
form 
solid
color 
white
Water Solubility 
Soluble in water (100mM)
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Safety Information

Safety Statements 
22-24/25
WGK Germany 
3

MSDS

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1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDE Usage And Synthesis

Chemical Properties

White Solid

Uses

1-Naphthylacetyl Spermine Trihydrochloride is a poliamine amide as potent Spermidine uptake inhibitor.

Biological Activity

naspm trihydrochloride is a selective antagonist of ca2+-permeable α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (ampa) receptors. ampa receptors are glutamate-gated ion channels that play central roles in the mammalian brain, mediating fast excitatory synaptic transmission and underlying several forms of synaptic plasticity. on excitatory neurons in adult animals, two types of ampa receptors are primarily expressed, namely heteromeric channels composed of glur1 and glur2 subunits (glur1/2 receptors), as well as channels composed of glur2 and glur3 subunits (glur2/3 receptors). naspm trihydrochloride blocks ampa receptors lacking the glur2 subunit, with an ic50 value of 0.3 μm for glur1 homomers.1. nilsen a, england pm. a subtype-selective, use-dependent inhibitor of native ampa receptors. journal of the american chemical society, 2007, 129(16): 4902-4903.2. koike m, iino m, ozawa s. blocking effect of 1-naphthyl acetyl spermine on ca2+-permeable ampa receptors in cultured rat hippocampal neurons. neuroscience research, 1997, 29(1): 27-36.

Biochem/physiol Actions

Blocks Ca2+ permeable AMPA receptor channels.

storage

+4°C (desiccate)

1-NAPHTHYLACETYL SPERMINE TRIHYDROCHLORIDESupplier

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